top of page

[1] H. Atsdr T. Olivia, J. Duke U. Corcoran, “Toxicological Profile for Dinitrophenols”, HHS Agency Toxic Subst. Dis. Regist., agosto, 1995.

[2] J. Grundlingh, P. I. Dargan, M. El-Zanfaly, D. M. Wood, “2,4-Dinitrophenol (DNP): A Weight Loss Agent with Significant Acute Toxicity and Risk of Death”, J. Med. Toxicol., vol. 7, pp. 205–212, 2011.

[3] M. Goldgof, C. Xiao, T. Chanturiya, W. Jou, O. Gavrilova, M. L. Reitman, “The chemical uncoupler 2,4-dinitrophenol (DNP) protects against diet-induced obesity and improves energy homeostasis in mice at thermoneutrality”, J. Biol. Chem., vol. 289, no. 28, pp. 19341–19350, 2014.

[4] http://www.interpol.int/News-and-media/News/2015/N2015-050

[5] 2,4-Dinitrophenol: A threat to Chinese body-conscious groups

[6] https://pubchem.ncbi.nlm.nih.gov/compound/2_4-dinitrophenol#section=Top
[7] https://toxnet.nlm.nih.gov/cgi-bin/sis/search2/f?./temp/~OoEjYm:3

[8]Food Standard Agency (2011) Food Standards Agency issues urgent advice on consumption of ‘fat burner’ capsules containing DNP”, 2011. Disponível em: http://tna.europarchive.org/20110116113217/http://www.food.gov.uk/news/pressreleases/2003/jun/fatburnpress.

[9] E. Colman, “Dinitrophenol and obesity: An early twentieth-century regulatory dilemma” Regul. Toxicol. Pharmacol., vol. 48, pp. 115–117, 2007.

[10] P. Le, B. Wood, S. P. Kumarasinghe, “Cutaneous drug toxicity from 2,4-dinitrophenol (DNP): Case report and histological description”, Australas. J. Dermatol., maio 2014, pp. 307–309, 2014.

[11]Woman died after accidental overdose of highly toxic diet pills”, 2015. Disponível em: http://www.theguardian.com/society/2015/jul/23/woman-died-accidental-overdose-highly-toxic-diet-pills-eloise-parry.

[12]Investigada morte de estudante que terá tomado produto para emagrecer”, 2015. Disponível em: https://www.publico.pt/sociedade/noticia/morte-de-estudante-que-tera-tomado-produto-para-emagrecer-esta-a-ser-investigada-1694752.

[13]Gym-obsessed dad given hours to live after ‘cooking his insides’ with diet pills”, 2015. Disponível em: http://www.thesun.co.uk/sol/homepage/news/6833390/Tragic-dad-given-hours-to-live-after-cooking-his-insides-with-controversial-diet-pills.html.

[14] F. Zack, V. Blaas, C. Goos, D. Rentsch, and A. Büttner, “Death within 44 days of 2,4-dinitrophenol intake”, Int. J. Legal Med., pp. 1–5, 2016.

[15] D. Vione, V. Maurino, C. Minero, E. Pelizzetti, “Aqueous atmospheric chemistry: Formation of 2,4-dinitrophenol upon nitration of 2-nitrophenol and 4-nitrophenol in solution” Environ. Sci. Technol., vol. 39, no. 20, pp. 7921–7931, 2005.

[16] a L. Risk, F. O. R. The, “Imminent threat 2,4-dinitrophenol (dnp)”, abril, pp. 2–4, 2015.

[17] Y. Lu, J. Jiang, W. Huang, “Clinical features and treatment in patients with acute 2,4-dinitrophenol poisoning”, J. Zhejiang Univ. Sci. B, vol. 12, no. 3, pp. 189–192, 2011.

[18] X. Zhao, J. Jiang, and Y. Lu, “Evaluation of efficacy of resin hemoperfusion in patients with acute 2 , 4-dinitrophenol poisoning by dynamic monitoring of plasma toxin concentration”, vol. 16, no. 8, pp. 720–726, 2015.

[19]Dantroleno - Infomed” Disponível em: http://www.infarmed.pt/infomed/detalhes.php?med_id=2342&dci=ZGFudHJvbGVubw==&nome_comer=&dosagem=&cnpem=&chnm=&forma_farmac=&atc=&disp=&estado_aim=&pesquisa_titular=&cft=&grupo_produto=&pagina=1.

Toxicologia Mecanística FFUP

Ana Sofia Costa | Bruno Freitas | Joana Miguel Silva 

bottom of page